BZINC Tablets (VITAMIN B-COMPLEX FORTIFIED WITH ZINC ) Back

COMPOSITION :
BZINC Tablets(each tablet contains)
Elemental Zinc
(As Zinc Sulphate Monohydrate) U.S.P.             54.6 mg
Vitamin B1                                                         10.0 mg
Vitamin B2                                                         10.0 mg
Vitamin B6                                                           3.0 mg
Vitamin B12                                                       15.0 mg
Niacinamide                                                       50.0 mg
Calcium Pantothenate                                       12.5 mg

CLINICAL PHARMACOLOGY :
Vitamin B1 (Thiamine) : Thiamine is not stored in the body. It gets converted to a coenzyme called Thiamine pyrophosphate (or Cocarboxylase) which decarboxylates apha-keto acids such as pyruvate and alpha-keto glutarate. Thiamine pyrophosphate also acts as the coenzyme of transketolase in the direct oxidative pathway of glucose metabolism. In thiamine deficiency, pyruvic acid and lactic acid accumulates in tissues. Deficiency of thiamine leads to fatigue, anorexia, gastro intestinal disturbance, tachycardia, irritability, and neurological symptoms. Beri-beri , a disease caused by vitamin B1 deficiency, is common in people whose diet is solely polished rice, in alcoholics, in pregnant women receiving an inadequate diet, and in people with malabsorption syndromes, prolonged diarrhea, or hepatic disease. As thiamine is essential for metabolism of carbohydrates, its requirement is greatest when carbohydrate is the major energy source.

Vitamin B2 (Riboflavin) : Riboflavin is the precursor of the coenzymes flavin mononucleotides (FMN) and flavin adenine dinuceotide (FAD), etc. All these derivatives of Riboflavin are widely involved as coenzymes in intermediary metabolism. FAD is the cofactor of glutathione reductase, the antioxidant enzyme that degrades reactive lipid peroxides. Riboflavin being precursor for FAD (a coenzyme), it may provide antioxidant activity. Early in the course of riboflavin deficiency, the patient may exhibit burning and itching of the eyes and mouth as well as personality disturbances. Later on, angular stomatitis, seborrheic dermatitis, glossitis, and other epithelial abnormalities are found. With further progression of the deficiency state, anemia and corneal neovascularization may develop.

Vitamin B6 (Pyridoxine) : Vitamin B6 has two main active derivatives, i.e., pyridoxal and pyridoxamine. Pyridoxal and Pyridoxamine phosphate are mainly involved as coenzymes, especially in the metabolic transformation of amino acids including transamination, decarboxylation, and recemization. Vitamin B6 is a cofactor in the conversion of tryptophan to 5-hydroxy tryptamine (5-HT) and of methionine to cysteine. Deficiency of Vitamin B6 occurs commonly in severe alcoholism, in association with deficiencies of other vitamins. Important features of vitamin B6 deficiancy observed in humans are related to the skin, nervous system, and erythropoiesis,. Seborrheic skin lession above the eyes, nose, and mouth accompanied by glossitis and stomatitis is common. In humans, peripheral neuritis, associated with synovial swelling and tenderness especially in the carpal synovia has been attributed to pyridoxine deficiency. The central feature of moderate pyridoxine deficiency is the decrease in the concentration of the neurotransmitters gamma-amino butyric acid (GABA), and 5-HT.

Vitamin B12 (Cyanocobalamin) : Cyanocobalamin is readily converted into the coenzymes, methylcobalamin, and deoxyadenosylcobalamin. Methylcobalamin is involved in the conversion of hemocysteine to methionine, and deoxydenosylcobalamin in the conversation of methylnalonyl-CoA to succinyl-CoA. These two active coenzymes of Vitamin B12 are essential for cell growth and respiration. The two clinical consequences of Vitamin B12 deficiency are Anemia and Neuropathy.
Niacinamide : Niacinamide is needed for the coenzymes NAD and NADP that catalyse tissue oxidation-reduction reactions. Dietary tryptophan is converted to Niacinamide by a vitamin B6 dependent pathway. So tryptophan deficiency in diet, leads to Niacinamide deficiency. Chronic dietary deficiency of Niacin(a form of Niacinamide) results in the disorder, pellagra, which is characterized by dermatitis, diarrhea, dementia, and ultimately death. High doses of Niacinamide (300 – 2500 mg. daily) have been of use in the treatment of various inflammatory skin lesions, including acne, dermatitis, herpetiformis, erythema elevatum diutinum, generalized granuloma annulare, bullous pemphigoid, polymorphous light eruption, and others. Inhibitory effects of Niacinamide on lymphocytes proliferation and transformations, histamine release from mast cells, and neutrophil function may be responsible for the therapeutic response. The therapeutic use of Niacinamide in diabetes is based upon its properties as an antioxidant, as an inhibitor of poly(ADP-ribose) polymerase and as a maintainer of intracellular NAD, but it is unclear which of these actions is important.

Calcium Pantothenate : Pantothenic acid (vitamin B3) is a starting compound for the production of the following coenzymes. Conezymes A(CoA-SH), dephospho Coenzyme A( dephospho -CoA-SH) and pantetheine 4’-phosphate (pp), which either occur in the cell in a free state or are bound to enzyme proteins. The coenzymes participate in reactions of Acyl group transfer; hence the name acylation (A) coenzyme. Deficiency may lead to a syndrome characterized by fatigue, headache, sleep disturbance, epigastric pain, muscle cramps and incoordination.

Zinc(as Zinc Sulphate) : Zinc is an essential trace mineral that is required for metabolic functions for our body.

  1. The principal function of zinc is through incorporations into certain enzymes-producting “Zinc activated enzymes” (catabolism).
  2. Zinc plays a critical role in protein synthesis (Anabolism).
  3. Zinc helps in the development of “immune function”. There are two ‘Zinc deficiency’ conditions.
    1. Hereditary zinc deficiency conditions.
    2. Non Hereditary zinc deficiency conditions.

The Hereditary zinc deficiency conditions is acrodermatitis enteropathica, a rare condition characterized by the triad of acral dermatitis (face, hands, feet, anogenital areas), alopecia, diarrhea. Clinical manifestations of moderate to severe zinc deficiency observed in non-hereditary conditions include rough dry skin, progressive severe acral dermatitis, angular stomatitis, seborrheic dermatitis like eruptions, alopecia, the defective embryogenesis, growth retardation in children & adolescents, and mental disturbances. Zinc also has an antioxidant role by acting as a co-factor of the antioxidant enzyme, superoxide dismutase.

INDICATIONS :

  1. Along with Antibiotics, BZINC Tablets  boosts immunity and hastens recovery.
  2. Liver Diseases & Alcoholism.
  3. Diabetes mellitus.
  4. Along with Oral Contraceptives.
  5. Promotes faster wound healing (surgical/accidental).
  6. Myocardial infraction.
  7. Aphthous ulcers.
  8. Gastric ulcers.
  9. Rheumatoid arthritis and macular degeneration.
  10. Dementia & behavioural disorders.
  11. Retarted growth.
  12. Pregnancy.
  13. Delayed puberty.
  14. Acne, Alopecia, Furunculosis, Seborrheic dermatitis, angular stomatitis, vitiligo, psoriasis and eczema.
  15. Anorexia.
  16. Hypothyroidism.

DOSAGE :
One tablet of BZINC daily or as directed by the physician.