COMPOSITION :
SA-6 Ointment
Salicylic Acid I.P. 6%w/w
In an ointment base
SA-12 Ointment Salicylic Acid I.P. 12%w/w
In an ointment base
Molecular formula
Salicylic Acid C7H6O2
CLINICAL PHARMACOLOGY :
The mechanism of action of topical salicylic acid in corn, callus, wart, & inflammatory hyperkeratoses may include two pathways, both leading to desquammation of corneocytes. Salicylic acid reduces intercellular cohesiveness of the horny cells by dissolving the intercellular cement material. Salicylic acid also reduces the pH of the stratum corneum, thereby increasing hydration and softening. In inflammatory hyperkeratoses, like psoriasis, ichythyosis, palmoplantar keratoderma, etc, the keratolytic action of SA-6 /SA-12 causes desquamation of stratum corneum, thereby ensuring better penetration of the topical corticosteroid (of desired potency) used separately.
INDICATIONS :
1. Calluses
2.Corns
3. Skin fissures.
4. To smooth rough skin associated with psoriasis, and other inflammatory hyperkeratoses [as an adjunct to UVA/PUVA treatment/ local steroid treatment]
5. Extra genital warts.
DOSAGE AND ADMINISTRATION :
Prior to application of SA-6 /SA-12 , soak the affected area in warm water for five minutes. Remove any loosened tissue by rubbing gently with a wash cloth. Dry area thoroughly. Apply a thin film of the ointment to the affected area two or three times a day.
WARNINGS AND PRECAUTIONS :
SA-6 & SA-12 are for external use only. SA-6 & SA-12 should not be used on irritated skin, on any area that is infected or reddened. Also not recommended for diabetics, or those with poor blood circulation. SA-6 & SA-12 should not be used on moles, birth marks, warts with hair growing from them, genital warts, or warts on the face or mucous membranes. Do not permit SA-6 & SA-12 to contact eyes (eyelids or skin near the eyes) or mucous membranes. If contact with eyes or mucous membranes occurs, immediately flush with water.
ADVERSE REACTIONS :
A localized irritant reaction may occur.
STORAGE INSTRUCTIONS :
Store in a cool, dry, dark place
