STERNON Gel/Cream/Lotion (TOPICAL CORTICOSTEROID)

COMPOSITION :
STERNON GEL & CREAM
Betamethasone (as Dipropionate)    0.05% w/w
In Propylene Glycol base
STERNON LOTION
Betamethasone (as Dipropionate)    0.05% w/v
In Propylene Glycol & Glycerin
(Non-aqueous base)
Betamethasone Dipropionate
Molecular Formula C28H37FO7

CLINICAL PHARMACOLOGY :
The primary therapeutic effect of Betamethasone dipropionate is due to the anti-inflammatory activity which is nonspecific. Topically applied glucocorticoids like Betamethasone dipropionate binds with receptor proteins in the cytoplasm of target cells. This leads to the formation of phospholipase A2 inhibitory proteins, collectively called lipocortins. Phospholipase A2 is known to catalyze the conversion of membrane phospholipids to Arachidonic acid. Arachidonic acid binds with cyclo-oxygenase to form highly inflammation prostaglandins, PGE2. Lipocortins inhibits phopholipase A2, and thereby controls the biosynthesis of potent mediators of inflammatory like prostaglandin E2 (PGE2) and leukotrienes, kinins, histamine, liposomal enzymes and the complement system. When applied to inflamed area of skin Betamethasone dipropionate inhibits the migration of leukocytes into the area by reversing vascular dilatation and permeability. The clinical result is a decrease in edema (swelling), erythema and pruritus. Betamethasone dipropionate falls under the category of very potent corticosteroids with a vasconstrictor potency index of 1660. Due to double esterification at positions 17&21, sternon becomes very lipophilic thereby offering
-better penetration
-more affinity to the cytosol receptors for potent action.

INDICATIONS :
STERNON GEL /CREAM /LOTION is indicates in inflammatory and pruritic manifestation of steroid responsive dermatoses. As an alternative/ adjunctive treatment in Psoriasis, Seborrheic dermatitis.
May be used concomitantly with antifungals for initial control of inflammatory symptoms.
STERNON LOTION is especially suited for application in and around hairy areas, and scalp.
Propylene glycol being the penetration enhancer ensures better penetration of Betamethasone Dipropionate.

DOSAGE AND ADMINISTRATION :
STERNON GEL /CREAM
A thin film has to be applied two or three times a day. Treatment should be limited to two weeks, and amounts greater than 50g. per week should not be used.
STERNON LOTION
Apply a few drops of STERNON LOTION to the affected area twice daily and massage lightly until the lotion disappears. Treatment must be limited to two weeks, and amounts greater than 50ml per week should not be used.

CONTRAINDICATIONS :
Sternon is contraindicated in patients who are hypersensitive to Betamethasone dipropionate, to other corticosteroids, or to any ingredients in these preparations.

WARNINGS AND PRECAUTIONS :
When applied to the eyelid or skin near the eyes, the drug may enter the eyes.

ADVERSE REACTIONS :
Burning, itching, irritation, dryness, folliculitis, skin atrophy, erythema, numbness of fingers and telangiectasia occurs infrequently. If signs of hypersensitivity occur, treatment should be immediately stopped.

STORAGE INSTRUCTIONS :
Store in a cool, dry place.